The TBPod

The TBPod is a podcast for clinicians and policymakers caring for patients with tuberculosis. The podcasts present discussions with expert clinicians, researchers, policymakers and advocates about their work in the field of tuberculosis. Tuberculosis remains one of the leading causes of death worldwide, and is an important contributor to morbidity among migrants arriving in Australia and New Zealand. There are around 1300 reported cases of TB in Australia each year, and a further 300 in New Zealand. Included in these figures are cases of multi-drug resistant (MDR) TB which pose significant barriers to treatment and management of the disease. The Australian government has committed to the global elimination of TB by 2030, but to do so requires the development of innovative new strategies, based on high-quality research, that has national and international reach. These podcasts aim to engage and update those who are interested in the field of tuberculosis through discussions with leaders in the field of tuberculosis.

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The TBPod

Vaccination in Tuberculosis

November 08, 2022 • Actnet

BCG has long been the only widely used vaccination strategy since it's initial use over 100 years ago. In high TB burden settings it is still recommended in children to protect against disseminated disease though the lasting protection offered by BCG vaccination has been poor at best.

Today, Emeritus Professor Warwick Britton AO FAHMS from the Centenary Institute and the University of Sydney speaks with Professor Greg Fox about how the BCG vaccine works and where it's utility lies. Professor Britton also explores exciting research in tuberculosis vaccines and what developments may be required to control tuberculosis in the future.

REFERENCES:
Hart, D'Arcy, and Sutherland. "BCG and vole bacillus vaccines in the prevention of tuberculosis in adolescence and early adult life." Br Med J 2.6082 (1977): 293-295.

Nemes, Elisa, et al. "Prevention of M. tuberculosis infection with H4: IC31 vaccine or BCG revaccination." New England Journal of Medicine 379.2 (2018): 138-149.

Darrah, Patricia, et al. "Prevention of tuberculosis in macaques after intravenous BCG immunization." Nature 577.7788 (2020): 95-102.