CATAPuLT - Can we manage latent TB infection in primary care? Artwork

The TBPod

The TBPod is a podcast for clinicians and policymakers caring for patients with tuberculosis. The podcasts present discussions with expert clinicians, researchers, policymakers and advocates about their work in the field of tuberculosis. Tuberculosis remains one of the leading causes of death worldwide, and is an important contributor to morbidity among migrants arriving in Australia and New Zealand. There are around 1300 reported cases of TB in Australia each year, and a further 300 in New Zealand. Included in these figures are cases of multi-drug resistant (MDR) TB which pose significant barriers to treatment and management of the disease. The Australian government has committed to the global elimination of TB by 2030, but to do so requires the development of innovative new strategies, based on high-quality research, that has national and international reach. These podcasts aim to engage and update those who are interested in the field of tuberculosis through discussions with leaders in the field of tuberculosis.

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CATAPuLT - Can we manage latent TB infection in primary care?

March 01, 2025 • Actnet

Dr Matthew Burman is a TB clinician and researcher from East London, Queen Mary University and the Blizzard Institute. Today he presents the data from the CATAPULT trial which randomised patients to either have their latent TB infection managed by a TB clinic in secondary care, or be managed in primary care by their GP in concert with a community pharmacist. This amazing trial re-evaluates how we think about TB preventative therapy and looks at new ways of approaching the burden of latent TB infection.

REFERENCES

Burman, M., et al. "Protocol for a cluster randomised control trial evaluating the efficacy and safety of treatment for latent tuberculosis infection in recent migrants within primary care: the CATAPuLT trial." BMC Public Health 19 (2019): 1-7.

Goswami, Neela D., et al. "Predictors of latent tuberculosis treatment initiation and completion at a US public health clinic: a prospective cohort study." BMC public health 12 (2012): 1-8.

Loutet, Miranda G., et al. "National roll-out of latent tuberculosis testing and treatment for new migrants in England: a retrospective evaluation in a high-incidence area." European Respiratory Journal 51.1 (2018).

Alsdurf, Hannah, et al. "The cascade of care in diagnosis and treatment of latent tuberculosis infection: a systematic review and meta-analysis." The Lancet Infectious Diseases 16.11 (2016): 1269-1278.